Effects of allopurinol and febuxostat on uric acid transport and transporter expression in human umbilical vein endothelial cells (TURBO project)

DANS Data Station Life Sciencesvia DANS Data Stations (via DataCite) · bijgewerkt 22 oktober 2026

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Uric acid induces radical oxygen species formation, endothelial inflammation, and endothelial dysfunction which contributes to the progression of atherosclerosis. Febuxostat and allopurinol differentially alter uric acid transporter function in human embryonic kidney cells. We hypothesized that endothelial cells express uric acid transporters that regulate intracellular uric acid concentration and that modulation of these transporters by febuxostat and allopurinol contributes to their different impact on cardiovascular mortality. Gene expression of uric acid transporters was determined in isolated human umbilical vein endothelial cells (HUVEC) and in human aortic endothelial cells (HAEC). Cultured HUVEC were studied for the effect of allopurinol and febuxostat on intracellular uric acid concentrations, gene expression of uric acid transporters, and cell count after exposure to uric acid in medium. Data is reported as median (range). HUVEC and HAEC expressed glucose transporter 9 (GLUT9), multidrug resistance protein 4 (MRP4), breast cancer resistance protein (BRCP), and sodium-dependent dicarboxylate transporter (NaDC3) at mRNA level. Allopurinol did not affect intracellular uric …

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